Mast Cell Activation Disorders Research
14 total studies as of March 2, 2022
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Introduction
MCAS: DIAGNOSIS, CLASSIFICATION, AND MANAGEMENT
Valent, P., Akin, C., Nedoszytko, B., Bonadonna, P., Hartmann, K., Niedoszytko, M., Brockow, K., Siebenhaar, F., Triggiani, M., Arock, M., Romantowski, J., Górska, A., Schwartz, L., & Metcalfe, D. (2020). Diagnosis, Classification and Management of Mast Cell Activation Syndromes (MCAS) in the Era of Personalized Medicine. International Journal of Molecular Sciences, 21(23), 9030. https://doi.org/10.3390/ijms21239030
This review article details MCAS and the signs, symptoms, diagnostic (laboratory assessments), diagnostic criteria, differential diagnoses, genetic predispositions, and management of MCAS.
Summary by Kimberly Czotter
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MAST CELL DISORDERS: DEFINITIONS, CRITERIA, AND CLASSIFICATIONS
Valent, P. et al. (2012). Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal. International Archives of Allergy and Immunology, 157(3), 215–225. https://doi.org/10.1159/000328760
This proposal details the difference between two mast cell conditions mastocytosis and mast cell activation disorders: primary MCAS, secondary MCAS, and idiopathic MCAS. The diagnostic criteria for MCA has new robust diagnostic criteria to reduce misdiagnosis: clinical symptoms, tryptase levels, other mast cell mediators (histamine, prostaglandin D2, urinary metabolites), and response to treatment.
Summary by Kimberly Czotter
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MCAS CLINICAL REVIEW
Frieri, M. (2015). Mast Cell Activation Syndrome. Clinical Reviews in Allergy & Immunology, 54(3), 353–365. https://doi.org/10.1007/s12016-015-8487-6
This review discusses previous and current MCAS diagnostic criteria and processes, along with symptomatology and a comparison to mastocytosis. Various treatment options and a review of mast cells functionality are also discussed.
Summary by Kimberly Czotter
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MAST CELLS AND THEIR ROLES
Krystel-Whittemore, M., Dileepan, K. N., & Wood, J. G. (2016). Mast Cell: A Multi-Functional Master Cell. Frontiers in Immunology, 6. https://doi.org/10.3389/fimmu.2015.00620
This is a detailed review of mast cells to explain their presence in connective tissues, activation, degranulation, and roles (vasodilation, vascular homeostasis, immune response, detoxification, and angiogenesis). They discuss the pathophysiology of diseases, malignancies, and cardiovascular disease.
Summary by Kimberly Czotter
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MCAS REVIEW
Frieri, M., Patel, R., & Celestin, J. (2012). Mast Cell Activation Syndrome: A Review. Current Allergy and Asthma Reports, 13(1), 27–32. https://doi.org/10.1007/s11882-012-0322-z
This review of MCAS details diagnostic criteria, symptoms, treatments, and a review of blood and urine testing for diagnosis. It also details the biochemical reactions of mast cells and their pathophysiological mechanisms.
Summary by Kimberly Czotter
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MCAS OVERVIEW
Matito, A., Escribese, M., Longo, N., Mayorga, C., Luengo-Sánchez, O., Pérez-Gordo, M., Matheu, V., Labrador-Horrillo, M., & Seoane-Reula, M. (2021). Clinical Approach to Mast Cell Activation Syndrome: A Practical Overview. Journal of Investigational Allergy and Clinical Immunology, 31(6), 461–470.
This review speaks about the diagnosis of MCAS with 3 criteria: clinical signs/symptoms, tryptase levels increase of >20% within 1-4 hours after an acute attack and response to anti-mediator therapy. The authors explore the assessment of clonal bone marrow mast cells as a diagnostic tool and focus on the evaluation and treatment for suspected MCAS.
Summary by Kimberly Czotter
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MCAS DIAGNOSTIC CRITERIA AND TOOLS
Leru, P., Anton, V., Ureche, C., Zurac, S., Bratu, O., & Neagoe, C. (2020). Mast cell activation syndromes ‑ evaluation of current diagnostic criteria and laboratory tools in clinical practice (Review). Experimental and Therapeutic Medicine. https://doi.org/10.3892/etm.2020.8947
This review details MCAS and its multiple subtypes, diagnostic criteria, mediators for mast cells, and differential diagnoses.
Summary by Kimberly Czotter
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MCAS DIAGNOSTIC REVIEW AND SUB-TYPES
Akin, C. (2017). Mast cell activation syndromes. Journal of Allergy and Clinical Immunology, 140(2), 349–355. https://doi.org/10.1016/j.jaci.2017.06.007
This review of MCAS discusses: validated markers of MCAS for diagnosis, different MCAS sub-categories, managements, and future directions for research.
Summary by Kimberly Czotter
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Life Quality
MAST CELLS AND THEIR ROLE IN PAIN AND NEUROINFLAMMATION
Theoharides, T. C., Tsilioni, I., & Bawazeer, M. (2019). Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. Frontiers in Cellular Neuroscience, 13. https://doi.org/10.3389/fncel.2019.00353
This review reports on mast cells and their role in fibromyalgia, with a theory that mast cells in the hypothalamus contribute to pain and inflammation by releasing neural sensitizing molecules. Presumably, these molecules may directly stimulate nociceptive (pain) neurons or through the microglial cells. Preusmably, inhibiting mast cell stimulation could reduce pain and fibromyalgia symptoms.
Summary by Kimberly Czotter
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Contraindications
Treatments, medications, and more that may aggravate Mast Cell Disorders.