Mast Cell Activation Syndrome Research
5 studies as of March, 2022
STUDIES APPEAR IN ORDER FROM OLDEST TO NEWEST ADDED
For navigation, click on the topic you are interested in below:
Circulatory System
Heart, veins, arteries, capillaries, and blood.
Digestive System
Teeth, esophagus, stomach, intestines, and vitamin/mineral deficiencies.
DIETARY FIBER AND MCAS AND MAST CELL DISEASES
Folkerts, J., Stadhouders, R., Redegeld, F. A., Tam, S. Y., Hendriks, R. W., Galli, S. J., & Maurer, M. (2018). Effect of Dietary Fiber and Metabolites on Mast Cell Activation and Mast Cell-Associated Diseases. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.01067
The authors suggest that the increased prevalence of mast cell related disorders in western countries may be related to the western diet through reduced fiber intake and related metabolites. Research has suggested that fiber can regulate B and T cell activation, but the information is scarce on the roll for mast cells. As mast cells are concentrated in vascularized tissue and the gut, they are exposed to fiber and related metabolites.
Summary by Kimberly Czotter
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MCAS FOR THE GASTROENTEROLOGIST
Weinstock, L. B., Pace, L. A., Rezaie, A., Afrin, L. B., & Molderings, G. J. (2020). Mast Cell Activation Syndrome: A Primer for the Gastroenterologist. Digestive Diseases and Sciences, 66(4), 965–982. https://doi.org/10.1007/s10620-020-06264-9
This review was written by mast cell specialists who reported on the most common GI symptoms caused by mast cells. They argue that these symptoms are often mistaken as functional GI disorders (especially IBS, dyspepsia, heartburn, and chronic/cyclic nausea) as the mast cell has only been recently recognized as significant for the GI tract. They cover topics such as: symptoms, comorbidities, diagnosis, and treatments.
Summary by Kimberly Czotter
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Hormones (Endocrine System)
How hormones and menstruation affect Mast Cell Disorders.
PROGESTERONE AND ESTROGEN INFLUENCES ON MAST CELLS
Zierau, O., Zenclussen, A. C., & Jensen, F. (2012). Role of female sex hormones, estradiol and progesterone, in mast cell behavior. Frontiers in Immunology, 3. https://doi.org/10.3389/fimmu.2012.00169
This review of mast cells and interaction with estradiol and progesterone is based off the premise that females have a higher prevalence of mast cell related pathologies. The authors discuss studies in mice, rats and humans which indicate higher prevalence of mast cell pathologies in women at reproductive age and in post-menopausal women with hormone replacement therapy. These hormones also induced mast cell maturation and degranulation.
Summary by Kimberly Czotter
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Immune System
Lymph nodes, white blood cells, and conditions we are likely to catch.
IMMUNOLOGY OF NON-CLONAL MCAS
Cardet, J. C., Castells, M. C., & Hamilton, M. J. (2012b). Immunology and Clinical Manifestations of Non-Clonal Mast Cell Activation Syndrome. Current Allergy and Asthma Reports, 13(1), 10–18. https://doi.org/10.1007/s11882-012-0326-8
This review shares information about the biology of mast cells (roles, mediators) and clinical aspects of non-clonal MCAS (idiopathic) including diagnosis, limitations, treatment, and special situations (ex bone marrow biopsy).
Summary by Kimberly Czotter
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MAST CELLS MODIFY AUTOIMMUNE DISEASE
Brown, M. A., & Hatfield, J. K. (2012). Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy? Frontiers in Immunology, 3. https://doi.org/10.3389/fimmu.2012.00147
The authors argue that there is substantial evidence for mast cell degranulation and its involvement in various autoimmune diseases (MS, rheumatoid arthritis, etc.) and that treating with mast cell stabilizing medications may help reduce disease. They then detail the functions of mast cells in immune and inflammatory responses which may promote tissue damage. They believe that mast cells are important targets for disease intervention.
Summary by Kimberly Czotter
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