PoTS and Dysautonomia Research
11 total studies as of April 17, 2022
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Introduction and Reviews
OVERVIEW OF POTS
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019). Postural Orthostatic Tachycardia Syndrome. Journal of the American College of Cardiology, 73(10), 1207–1228. https://doi.org/10.1016/j.jacc.2018.11.059
The review discusses the prevalence of POTS, pathophysiology, causes, comorbidities, potential subtypes, differential diagnoses, testing, and treatment from both neurological and cardiological perspectives.
Summary by Kimberly Czotter
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POTS: CROSS-SECTIONAL SURVEY
Shaw, B. H. ,et al. (2019). The face of postural tachycardia syndrome – insights from a large cross‐sectional online community‐based survey. Journal of Internal Medicine, 286(4), 438–448. Portico. https://doi.org/10.1111/joim.12895
This online, community survey of 4835 participants identified demographics, clinical features, and the course of POTS by patients formally diagnosed. POTS primarily affects white (93%), females (94%) that are of childbearing age - approximately half develop symptoms at age 14. This multisystemic condition often takes a long time to diagnose, following multiple misdiagnoses, and patients have various symptoms especially: lightheadedness (99%), tachycardia (97%), headache (94%), presyncope (94%), and concentration difficulties (94%).
Summary by Kimberly Czotter
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POTS REVIEW
Fedorowski, A. (2018). Postural orthostatic tachycardia syndrome: clinical presentation, etiology, and management. Journal of Internal Medicine, 285(4), 352–366. Portico. https://doi.org/10.1111/joim.12852
This review of POTS talks about prevalence, symptoms, potential causes, etiology hypotheses, diagnostic processes, treatments, and outcomes.
Summary by Kimberly Czotter
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THE HPV VACCINE AND POTS
Arana, J., Mba-Jonas, A., Jankosky, C., Lewis, P., Moro, P. L., Shimabukuro, T. T., & Cano, M. (2017). Reports of Postural Orthostatic Tachycardia Syndrome After Human Papillomavirus Vaccination in the Vaccine Adverse Event Reporting System. Journal of Adolescent Health, 61(5), 577–582. https://doi.org/10.1016/j.jadohealth.2017.08.004
The authors reviewed the VAERS Database from June 2006 - August 2015 to compare the incidence of HPV vaccine and PoTS. They found that 29 PoTS diagnoses were within 40, 735 vaccine adverse events following the HPV vaccine. The patients experienced PoTS within 0-90 days following the vaccine, although, 20 patients reported pre-existing medical conditions. They suggest that 1 PoTS case is reported per 6.5 million HPV vaccines.
Summary by Kimberly Czotter
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POTS AND ITS PRESENTATION IN WOMEN
Anjum, I., Sohail, W., Hatipoglu, B., & Wilson, R. (2018). Postural Orthostatic Tachycardia Syndrome and Its Unusual Presenting Complaints in Women: A Literature Minireview. Cureus. https://doi.org/10.7759/cureus.2435
This review introduces PoTS and its symptoms, arguing that it is incredibly misdiagnosed and lacks approved treatments. They touch on the co-morbidities often associated with PoTS and women.
Summary by Kimberly Czotter
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HPV VACCINATION AND POTS
Butts, B. N., Fischer, P. R., & Mack, K. J. (2017). Human Papillomavirus Vaccine and Postural Orthostatic Tachycardia Syndrome: A Review of Current Literature. Journal of Child Neurology, 32(11), 956–965. https://doi.org/10.1177/0883073817718731
This article reviews the association between the HPV vaccine and adverse events, including PoTS. They use a variety of sources: literature, medical advisory committtes, and government statements. The authors argue that there is not enough evidence suggesting a causal relationship betweent the vaccine and PoTS due to a lack of control population.
Summary by Kimberly Czotter
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Life Quality
Understanding how PoTS and Dysautonomia affect the quality of life of patients.
Contraindications
Treatments, medications, and more that may aggravate PoTS and Dysautonomia
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Treatment Options
DIETARY INTERVENTION FOR POTS AND HSD
Do, T., Diamond, S., Green, C., & Warren, M. (2021). Nutritional Implications of Patients with Dysautonomia and Hypermobility Syndromes. Current nutrition reports, 10(4), 324–333. https://doi.org/10.1007/s13668-021-00373-1
"This review investigates dietary interventions that have helped reduce symptoms and improve quality of life within patients with POTS, hypermobility, and hEDS. They discuss demographics, symptom overlap, GI symptoms, and nutritional management. They argue that evidence suggests including probiotic and prebiotic-rich foods, fiber supplementation, salt, high fluid intake, and supplement use.
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Summary by Kimberly Czotter
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OCCUPATIONAL THERAPY WITH EDS AND POTS PATIENTS
Levine, D., Work, B., McDonald, S., Harty, N., Mabe, C., Powell, A., & Sanford, G. (2021). Occupational Therapy Interventions for Clients with Ehlers-Danlos Syndrome (EDS) in the Presence of Postural Orthostatic Tachycardia Syndrome (POTS). Occupational Therapy In Health Care, 1–18. https://doi.org/10.1080/07380577.2021.1975200
The authors discuss occupational therapy to treat patients with EDS and PoTS to improve their well-being, symptoms, employability, participation in daily life, and improve overall quality of life. These interventions include environmental modifications, adaptive equipment, orthoses, exercises, pacing/energy conservation, sleep routines, and habit development.
Summary by Kimberly Czotter
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Surgical Consideration
A discussion of anesthetics and appropriate surgery procedures in patients.